Inherited heart disease is the next frontier of cardiovascular research discovery. There are thousands of genes in the genome, but there is still a lot still unknown about how all these genes work and how they interact together
Reference: Titus EW, Deiter FH, Shi C, Wojciak J, Scheinman M, Jura N, Deo RC. The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia. Nat Struct Mol Biol. 2020 Dec;27(12):1142-1151. PMID: 33046906
We are actively growing a biobank of DNA from patients with a range of inherited cardiovascular conditions. The biobank is a valuable resource for approved researchers to make new DNA discoveries.
A first-of-its-kind NIH-funded study examining the causes of sudden deaths in the County of San Francisco, to help understand the role of genetics in sudden death.
We and our partners are making stem cells and doing comprehensive genetic analysis of samples from people with a range of cardiovascular conditions. This helps us understand the biology of these conditions on a much deeper level.
In some families, multiple family members have been affected by the same cardiovascular condition but genetic testing cannot find the cause. By doing comprehensive genetic analysis of these families, we hope to discover new genetic causes.
We are actively growing a biobank of DNA from patients with a range of inherited cardiovascular conditions. The biobank is a valuable resource for approved researchers to make new DNA discoveries.
"MyPeak-1 trial
We are part of a multi-site clinical trial testing a potential gene therapy for people with HCM caused by a mutation in the MYBPC3 gene".
PKP2- ARVC Natural History Study
We are monitoring disease progression in patients with PKP2 mutation-associated ARVC over a five-year long study.
RIDGE trial
We are part of a multi-site clinical trial testing a potential gene therapy for people with ARVC caused by a mutation in the PKP2 gene.
Patients interested in learning more about our research studies should contact the study coordinator by email at [email protected].
Researchers interested in collaborating with us are encouraged to contact us at [email protected].
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